Method of using vitamin D.sub.3 analogs with bis C-20 side chains
US6008209A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 16, 1998 |
| Grant date | Dec 28, 1999 |
| Priority date | — |
| Expiry date | Apr 16, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/593
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin D.sub.3 analog of the Formula I wherein: PA1 X is H.sub.2 or CH.sub.2 ; PA1 Y is hydrogen, hydroxy or fluorine; PA1 Z is hydroxy; PA1 R.sub.1 and R.sub.2 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.1 and R.sub.2 together with C.sub.25 form a (C.sub.3 -C.sub.6) cycloalkyl or cyclofluoroalkyl; PA1 R.sub.3 and R.sub.4 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.3 and R.sub.4 together with C.sub.25' form a (C.sub.3 -C.sub.6)cycloalkyl or cyclofluoroalkyl; PA1 A is a single bond or a double bond; PA1 B.sub.1 is a single bond, an E-double bond, a Z-double bond or a triple bond; and PA1 B.sub.2 is a single bond, an E-double bond, a Z-double bond or a triple bond; or a prodrug thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.