Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A · kind A · utility
26Cited by
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9Claims
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Key dates
| Filing date | Dec 12, 1997 |
| Grant date | Jan 11, 2000 |
| Priority date | — |
| Expiry date | Dec 12, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/438
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed spiro-substituted azacycles of formula I: (wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, k, l and m are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.