Substituted phenethylsulfones and method of reducing TNF.alpha. levels
US6020358A · kind A · utility
136Cited by
4References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 30, 1998 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Oct 30, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Phenethylsulfones substituted in the position .alpha. to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF.alpha. in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline- 1,3-dione and 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindoline- 1,3-dione.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.