Nucleoside modifications by palladium catalyzed methods
US6020483A · kind A · utility
52Cited by
10References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1998 |
| Grant date | Feb 1, 2000 |
| Priority date | — |
| Expiry date | Sep 25, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.