Macrolide LHRH antagonists

US6020521A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• John T. Randolph · Libertyville, US
• Fortuna Haviv · Rehovot, IL
• Daryl Sauer · Pleasant Prairie, US
• Philip Waid · Indianapolis, US
• Charles J. Nichols · Greendale, US
• Nicholas A. Mort · Waukegan, US
• Christopher R. Dalton · Mundelein, US
• Jonathan Greer · Chicago, US

Key dates

• Filing date: Aug 26, 1998
• Grant date: Feb 1, 2000
• Expiry date: Aug 26, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythrolide A derivatives which are antagonists of luteinizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.