Platelet aggregation inhibiting compounds

US6028087A · kind A · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• William E. Bondinell · Wayne, US
• James Francis Callahan · Philadelphia, US
• William F. Huffman · Malvern, US
• Richard M. Keenan · Malvern, US
• Brian W. Metcalf · Moraga, US
• James Samanen · Phoenixville, US
• Tobias O. Yellin · Wallingford, US

Key dates

• Filing date: Jan 21, 1998
• Grant date: Feb 22, 2000
• Expiry date: Jan 21, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I): EQU W--Z--(CR'R.sup.10).sub.r --U--(CR'.sub.2).sub.s --V--A (I) wherein: PA1 A is ##STR1## W is .sup.N ; Z is (CH.sub.2).sub.1-2 ; PA1 U and V independently are present as CO, CR'.sub.2, C(.dbd.CR'.sub.2), S(O).sub.r, O, NR', CR'OR', CR'(OR")CR'.sub.2, CR'.sub.2 CR'(OR"), C(O)CR'.sub.2, CR'.sub.2 C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O).sub.r NR', NR'S(O).sub.r, N.dbd.N, NR'NR', NR'CR'.sub.2, NR'CR'.sub.2, CR'.sub.2 O, OCR'.sub.2, C.tbd.C, CR'.dbd.CR', or CR'(NR'R")C(O); PA1 each r independently is 0 to 3; PA1 s is 0 to 2; PA1 each R' independently is H, C.sub.1-4 alkyl, C.sub.3-7 cycloalky-C.sub.0-4 alkyl, or Ar-C.sub.0-4 alkyl; PA1 each R" independently is R', --C(O)R', or --C(O)OR.sup.15 ; PA1 R.sup.10 is H, C.sub.1-4 alkyl, or --NR'R'; PA1 each R.sup.15 independently is C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl-C.sub.0-4 alkyl, or Ar-C.sub.0-4 alkyl; PA1 R.sup.2 is present once or twice as C.sub.1-4 alkyl, J--CO.sub.2 R', CONR', SR', NR'R", C .sub.1-4 alkoxy, hydroxy, CN, CF.sub.3, halo, or ##STR2## with the proviso that at least one R.sup.2 is J--CO.sub.2 R; and J is a single bond, --OCR'.sub.2 --, --NR'CR'.sub.2 --, CR'.…