Peptide conjugates for transfecting cells
US6030602A · kind A · utility
0Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1997 |
| Grant date | Feb 29, 2000 |
| Priority date | — |
| Expiry date | Jan 14, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to conjugates of lipids and basic, membrane disturbing peptides, particularly compounds of the formula EQU (R--CONH).sub.n --R.sup.3 (I) and EQU (R--S--S).sub.n --R.sup.3 (II) wherein R is the hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid, or a phospholipid moiety having a free valence bond; R.sup.3 is a basic membrane disturbing peptide having a free valence bond at one or two carbon atom(s); and n is 1 or 2. These conjugates can be used as a vector for transfecting a cell with a polynucleotide or any other anionic macromolecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.