Vitamin D derivatives

US6043385A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Pierre Barbier · Paris, FR
• Franz Bauer · Herzogenaurach, DE
• Peter Mohr · Basel, CH
• Marc Muller · Wolfersdorf, FR
• Wolfgang Pirson · Weil am Rhein, DE

Key dates

• Filing date: Dec 1, 1998
• Grant date: Mar 28, 2000
• Expiry date: Dec 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C401/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to vitamin D derivatives of the formula I ##STR1## wherein X is C.dbd.CH.sub.2 or CH.sub.2 ; PA0 Y is hydrogen, fluorine or hydroxy PA0 Z is hydroxy PA0 n is 1 or 2 PA0 R.sup.1 is lower alkyl, PA0 R.sup.2 is a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents, or is a phenyl group which is unsubstituted or substituted with a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents; and the dotted carbon-carbon bond in ring D is --C--C-- or --C.dbd.C--; or a pharmaceutically usable salt thereof.