Heterocyclic vinyl ethers

US6054588A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Geo Adam · Schopfheim, DE
• Sabine Kolczewski · Lörrach, DE
• Vincent Mutel · Mulhouse, FR
• Heinz Stadler · Basel, CH
• Jurgen Wichmann · Steinen, DE
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: May 4, 1999
• Grant date: Apr 25, 2000
• Expiry date: May 4, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of the formula ##STR1## wherein R signifies halogen or lower alkyl; PA1 n signifies 0-3; PA1 R.sup.1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substituted by amino, lower alkyl-amino or di-lower alkylamino; acetyl or cycloalkyl-carbonyl; and ##STR2## signifies an aromatic 5-membered residue which is bonded via a N-atom and which contains further 1-3 N atoms in addition to the linking N atom, as well as their pharmaceutically acceptable salts as therapeutically active substances, especially for the control or prevention of acute and/or chronic neurological disorders.