Variants of vascular endothelial cell growth factor
US6057428A · kind A · utility
39Cited by
13References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1996 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Aug 2, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect to binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within the VEGF compound domains. The variants hereof define those two binding regions and modify them so as to introduce changes that interrupt the binding to the respective domain. In this fashion the final biological characteristics of the VEGF molecule are selectively modified.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.