Recombinant human IGA-J. chain dimer

US6063905A · kind A · utility

Assignees

• The Board of Regents of the University of Texas System · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• J. Donald Capra · Dallas, US
• Jonathan Mark Hexham · Dallas, US
• Leon N. Carayannopoulos · Chesterfield, US
• Edward E. Max · Bethesda, US

Key dates

• Filing date: Jan 7, 1997
• Grant date: May 16, 2000
• Expiry date: Jan 7, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compositions and methods of use that comprise engineered IgA antibodies that, when administered to a host are secreted across the epithelium into the mucosal barriers of the body providing external passive immunotherapy against agents such as viral, bacterial and eukaryotic pathogens. Also disclosed are mini antibodies comprising the minimal transcytosis domains.