Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
US6066662A · kind A · utility
4Cited by
9References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 1996 |
| Grant date | May 23, 2000 |
| Priority date | — |
| Expiry date | Nov 20, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides hydroxylamine derivatives of formula (I) wherein A, R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. They are therefore useful for the control or prevention of degenerative joints diseases such as rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis. They can be manufactured according to generally known methods. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.