Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells
US6083751A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1995 |
| Grant date | Jul 4, 2000 |
| Priority date | — |
| Expiry date | Nov 1, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a T.sub.H -independent autocrine cycle) in response to adhesion between the lymphocyte and an antigen displaying cell (ADC) that might not normally activate the T cell. The chimeric receptors of the present invention comprise fusion polypeptides of the following structure: EQU XC--TM--IC28 wherein (XC) is an extracellular region derived from a receptor for a ligand that is expressed on the surface of an antigen-displaying cell, fused via a transmembrane region is (TM) to an intracellular region (IC28) which is derived from the intracellular region of the CD28 receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.