Lipoic acid analogs

US6090842A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Lester Packer · Berkeley, US
• Oren Tirosh · Berkeley, US
• Chandan K. Sen · Columbus, US
• Sashwati Roy · New Albany, US

Key dates

• Filing date: Mar 10, 1998
• Grant date: Jul 18, 2000
• Expiry date: Mar 10, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound is provided having the formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently denote a methylene, ethylene or unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in the unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, PA0 R.sup.3 and R.sup.4 PA1 (i) independently denote PA2 (a) hydrogen, PA2 (b) a methyl, ethyl, vinyl or unbranched or branched C.sub.3-16 alkyl, alkenyl or alkynyl group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in said unbranched or branched C.sub.3-16 alkyl, alkenyl or alkynyl group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, PA2 (c) a cycloalkyl, alkylcycloalkyl, alkenylcycloalkyl or alkynylcycloalkyl group having 5 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or PA2 (d) an aryl, alkaryl, aralkyl, alkenylaryl, aralkenyl, alkynylaryl …