Methods and compositions for the specific coagulation of vasculature

US6093399A · kind A · utility

Assignees

• The Board of Regents of the University of Texas System · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Philip E. Thorpe · Dallas, US
• Thomas S. Edgington · Village of La Jolla, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jul 25, 2000
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using a bispecific antibody.