Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6093573A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 20, 1997 |
| Grant date | Jul 25, 2000 |
| Priority date | — |
| Expiry date | Jun 20, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a crystallized Bactericidal Permeability-Increasing (BPI) protein; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.