Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US6096551A · kind A · utility
99Cited by
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7Claims
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Key dates
| Filing date | Sep 16, 1997 |
| Grant date | Aug 1, 2000 |
| Priority date | — |
| Expiry date | Sep 16, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.