Gamma-heregulin
US6096873A · kind A · utility
41Cited by
3References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 10, 1997 |
| Grant date | Aug 1, 2000 |
| Priority date | — |
| Expiry date | Jul 10, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/971
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel member of the heregulin superfamily has been identified which is designated ".gamma.-HRG". This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. .gamma.-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of .gamma.-HRG nucleic acid for the recombinant production of .gamma.-HRG). .gamma.-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.