Unsaturated amino acid derivatives

US6103743A · kind A · utility

Assignee

• Allelix Neuroscience Inc. · CA

Inventors

• Stanley C. Bell · Narberth, US
• Kathleen Da Silva · Schreiber, CA
• Allen Hopper · Glen Rock, US
• Methvin Isaac · Toronto, CA
• Eric A. Meade · Fanwood, US
• Vassil Ilya Ognyanov · Princeton, US
• Abdelmalik Slassi · Mississauga, CA

Key dates

• Filing date: Aug 6, 1999
• Grant date: Aug 15, 2000
• Expiry date: Aug 6, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compounds having the general formula: ##STR1## Ar.sub.1 and Ar.sub.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above; wherein any cycloalkyl or aryl substituent is linked to Ar.sub.1 or Ar.sub.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4; wherein Ar.sub.1 and Ar.sub.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group; R is H, alkyl or the counter ion for a basic addition salt; R.sub.1 and R.sub.2 are independently selected from the group consisting of H, …