D-proline derivatives

US6103910A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Cornelia Hertel · Münchenstein, CH
• Torsten Hoffmann · Weil am Rhein, DE
• Roland Jakob-Roetne · Inzlingen, DE
• Roger Norcross · Olsberg, CH

Key dates

• Filing date: Oct 27, 1998
• Grant date: Aug 15, 2000
• Expiry date: Oct 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D419/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New compounds have the formula: ##STR1## wherein R, R.sup.1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.