Systematic evolution of ligands by exponential enrichment: tissue selex
US6114120A · kind A · utility
36Cited by
6References
10Claims
0Family size
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Key dates
| Filing date | Oct 28, 1997 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Oct 28, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets, including cell surface macromolecules. The nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched and the high affinity nucleic acids are amplified for further partitioning. The high affinity nucleic acid ligands are useful in capturing target cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.