Synthesis of sulfurized oligonucleotides
US6114519A · kind A · utility
18Cited by
3References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 15, 1997 |
| Grant date | Sep 5, 2000 |
| Priority date | — |
| Expiry date | Oct 15, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.