Nucleic acid encoding adhesion variants
US6117655A · kind A · utility
51Cited by
13References
30Claims
0Family size
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Key dates
| Filing date | Jun 1, 1995 |
| Grant date | Sep 12, 2000 |
| Priority date | — |
| Expiry date | Jun 1, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.