Rapid detection of antibiotic resistance in mycobacterium tuberculosis
US6124098A · kind A · utility
5Cited by
3References
9Claims
0Family size
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Key dates
| Filing date | May 20, 1998 |
| Grant date | Sep 26, 2000 |
| Priority date | — |
| Expiry date | May 20, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A nucleotide sequence encoding a katG/lacZ fusion protein is useful for assaying the enzymatic activity of the katG gene product. A process of selecting a compound that is toxic against an isoniazid-resistant mycobaterial strain comprises incubating a catalase peroxidase enzyme with an isoniazid to produce a compound that restores isoniazid susceptability to the isoniazid-resistant mycobaterial strain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.