Chimeric adenoviral coat protein and methods of using same
US6127525A · kind A · utility
55Cited by
37References
48Claims
0Family size
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Key dates
| Filing date | Mar 13, 1997 |
| Grant date | Oct 3, 2000 |
| Priority date | — |
| Expiry date | Mar 13, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.