Certain amido- and amino- substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
US6133265A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 18, 1997 |
| Grant date | Oct 17, 2000 |
| Priority date | — |
| Expiry date | Jul 18, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/155
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amido, amino and sulfonamide substituted benzylamine derivatives useful in treating eating disorders have the formula ##STR1## where X.sub.1, X.sub.2, and X.sub.3, independently represent substituents of formula ##STR2## D=H, lower straight or branched chain alkyl having 1-6 carbon atoms, a methylene unit incorporated into a ring connected with G as in the cases of pyrrolidine, pyrrolidone, piperidine, and piperidone; E=O or H.sub.2 ; O=0 or 1; G=straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, aryl substituted with halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, heteroaryl--selected from the group consisting of 2-, 3-, or 4-pyridyl, 2-pyrazyl, 2-, or 3-thienyl, 2-pyrazinyl, 2-, 3-, or 4-quinolyl, 1-, 3-, or 4-isoquinolyl, 2-quinoxalyl, 3-, or 4-cinnolyl, said heteroaryl substituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms; and A, T and R.sub.1 -R.sub.4 are hydrogen or organic substituents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.