Heregulin variants
US6136558A · kind A · utility
24Cited by
3References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 9, 1998 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Feb 9, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/57509
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.