Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor antagonists

US6140341A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Holger Heitsch · Hofheim, DE
• Adalbert Wagner · Gersthofen, DE
• Klaus Wirth · Frankfurt am Main, DE
• Bernward Scholkens · Kelkheim, DE
• Gerhard Nolken · Pocking, DE

Key dates

• Filing date: Mar 12, 1997
• Grant date: Oct 31, 2000
• Expiry date: Mar 12, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aminoalkyl and acylaminoalkyl ethers which are distinguished by high affinity for the bradykinin B.sub.2 receptor and improved solubility in water are described. These aminoalkyl and acylaminoalkyl ethers can be represented by the formula (I) ##STR1## in which R.sup.1,R.sup.2,R.sup.3 are alkyl, aryl, alkylaryl, halogen, hydrogen, cycloalkyl, CHO, CO--O-alkyl, COOH; R.sup.4, R.sup.5 are hydrogen, halogen, alkoxy, nitro, cyano, S-alkyl; n is a number from 1 to 8; R.sup.6 is hydrogen, alkyl, alkylalkenyl, alkylaryl; R.sup.7 is hydrogen and a substituted or unsubstituted acyl radical. A process for preparing the compounds of the formula (I) is likewise described.