Nucleic acid that encodes a chimeric adenoviral coat protein
US6153435A · kind A · utility
26Cited by
38References
32Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 17, 1999 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Jun 17, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.