Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
US6153599A · kind A · utility
1Cited by
18References
9Claims
0Family size
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Key dates
| Filing date | Jan 19, 1999 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Jan 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3533
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.