Inhibitors of glycogen synthase 3 kinase

US6153618A · kind A · utility

Assignee

• Chiron Corporation · US

Inventors

• Peter G. Schultz · Village of La Jolla, US
• David B. Ring · Palo Alto, US
• Stephen Harrison · Benicia, US
• Andrew M. Bray · Elmore, AU

Key dates

• Filing date: Oct 10, 1997
• Grant date: Nov 28, 2000
• Expiry date: Oct 10, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.