Point mutants of N.gradient.2 CSF-1 and carboxy truncated fragments thereof
US6156300A · kind A · utility
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19References
43Claims
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Key dates
| Filing date | Apr 21, 1995 |
| Grant date | Dec 5, 2000 |
| Priority date | — |
| Expiry date | Apr 21, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.