Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
US6162613A · kind A · utility
41Cited by
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9Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 18, 1998 |
| Grant date | Dec 19, 2000 |
| Priority date | — |
| Expiry date | Feb 18, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9121
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.