Process for the manufacture of bisphosphine oxide and bisphosphonate compounds
US6162929A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1998 |
| Grant date | Dec 19, 2000 |
| Priority date | — |
| Expiry date | Dec 15, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/655354
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the manufacture of bisphosphine oxide compounds and bisphosphonates as intermediates for the production of bisphosphine ligands, in which in a single step process PA1 a) a phosphine oxide compound is reacted in an organic solvent at -70.degree. C. to 20.degree. C. with 0.5-3 eq. of a lithium or magnesium amide compound, PA1 b) 0.5-3 eq. of oxidatively-acting metal salt or metal salt complex are added to the suspension obtained in stage a) in a temperature range of -70.degree. C. to 20.degree. C., with a racemate of a bisphosphine oxide compound being obtained; PA1 c) a racemate cleavage is carried out if desired; and PA1 d) the bisphosphonates obtained in stage b) or c) are converted into bisphosphine oxides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.