Amino acid derivatives

US6166072A · kind A · utility

Assignee

• Allelix Neuroscience Inc. · CA

Inventors

• Stanley C. Bell · Narberth, US
• Michael De Vivo · New York, US
• Allen Hopper · Glen Rock, US
• Methvin Isaac · Toronto, CA
• Anne O'Brien · Schreiber, CA
• Vassil Ilya Ognyanov · Princeton, US
• Richard Schumacher · Rochester, US

Key dates

• Filing date: Jun 29, 1999
• Grant date: Dec 26, 2000
• Expiry date: Jun 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/60
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are compounds having the general formula: ##STR1## wherein: Ar.sup.1 and Ar.sup.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above; wherein any cycloalkyl or aryl substituent is linked to Ar.sup.1 or Ar.sup.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4; wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group; wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alken…