Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions

US6166197A · kind A · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Phillip Dan Cook · Carlsbad, US
• Yogesh S. Sanghvi · Encinitas, US
• Kelly G. Sprankle · Vista, US
• Bruce Ross · Carlsbad, US
• Rich Griffey · Vista, US

Key dates

• Filing date: Mar 6, 1995
• Grant date: Dec 26, 2000
• Expiry date: Mar 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position.