CIF150/hTAFII150 is necessary for cell cycle progression
US6174679A · kind A · utility
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26Claims
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Key dates
| Filing date | Dec 10, 1998 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Dec 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A human protein termed CIF150/hTAF.sub.II 150 recognizes and selects TATA-less core promoters for cell cycle specific genes. Thus, CIF150/hTAF.sub.II 150 plays an important and selective role in establishing gene expression patterns necessary for progression through the cell cycle. The CIF150/hTAF.sub.II 150 gene and its expression products can be used to alter the spatial or temporal patterns of mitosis or cell cycle progression of a human cell and to treat disorders involving alterations in the regulation of mitosis or cell cycle progression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.