Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
US6187786A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1999 |
| Grant date | Feb 13, 2001 |
| Priority date | — |
| Expiry date | Dec 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D455/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention concerns compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; --A-- is a bivalent radical of formula; R.sup.1 and R.sup.2 each independently are hydrogen, hydroxy, halo, cyano, C.sub.1-6 alkyl, trihalomethyl, trihalomethoxy, C.sub.2-6 alkenyl, C.sub.1-6 alkyloxy, hydroxyC.sub.1-6 alkyloxy, C.sub.1-6 alkyloxyC.sub.1-6 alkyloxy, C.sub.1-6 alkyloxycarbonyl, aminoC.sub.1-6 alkyloxy, mono- or di(C.sub.1-6 alkyl)aminoC.sub.1-6 alkyloxy, Ar, Ar--C.sub.1-6 alkyl, Ar-oxy, Ar--C.sub.1-6 alkyloxy; or when on adjacent positions R.sup.1 and R.sup.2 taken together may form a bivalent radical; R.sup.3 and R.sup.4 each independently are hydrogen, halo, cyano, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, Ar-oxy, C.sub.1-6 alkylthio, di(C.sub.1-6 alkyl)amino, trihalomethyl, trihalomethoxy, or when on adjacent positions R.sup.3 and R.sup.4 taken together may form a bivalent radical; R.sup.5 is an imidazolyl substituted with hydrogen or C.sub.1-6 alkyl; R.sup.6 hydrogen, hydroxy, halo, cyano, optionally substituted C.sub.1-6 alkyl, C.sub.1-6 a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.