2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the C.N.S. and the heart
US6191152A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 20, 1999 |
| Grant date | Feb 20, 2001 |
| Priority date | — |
| Expiry date | Sep 20, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention refers to novel 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives of formula (I) having an influence on the heart and the central nervous system, furthermore pharmaceutical compositions containing the above derivatives, and a process for the preparations of the novel compounds. In formula (I) R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group of a phenyl group optionally substituted by 1 to 3 substituents selected from the group defined in the application, Z stands for a hydrogen atom of a C.sub.1-4 alkoxy group, R.sup.0 means a group of the formula Alk--NR.sup.4 R.sup.5 wherein Alk is a C.sub.1-6 straight of branched chain alkylene group, R.sup.4 and R.sup.5 represent, independently, a hydrogen atom, a C.sub.2-6 alkenyl group, a C.sub.1-8 alkyl group optionally substituted by a substituent selected from the group defined in the application or R.sup.4 and R.sup.5 form together with the adjacent nitrogen atom and optionally with one or more further nitrogen and/or oxygen and/or sulfur atom(s) a 5- to 10-membered saturated heterocyclic group, optionally substituted, one of R.sup.2 and R.sup.3 is an amino group, while the other stands for an amino group of a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.