Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
US6194390A · kind A · utility
7Cited by
9References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 3, 2000 |
| Grant date | Feb 27, 2001 |
| Priority date | — |
| Expiry date | Feb 3, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.