Cells expressing both human CD4 and a human fusion accessory factor associated with HIV infection

US6197578A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Edward A. Berger · Rockville, US
• Yu Feng · Cliffside Park, US
• Paul E. Kennedy · Tulsa, US
• Christopher C. Broder · Silver Spring, US

Key dates

• Filing date: Jan 30, 1997
• Grant date: Mar 6, 2001
• Expiry date: Jan 30, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The susceptibility to human immunodeficiency virus (HIV) infection depends on the cell surface expression of the human CD4 molecule and a human fusion accessory factor associated with HIV infection (CXCR4). CXCR4 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CXCR4 plays an essential role in the membrane fusion step of HIV infection. The establishment of stable cell lines that coexpress human CD4 and CXCR4 provides valuable tools for the continuing research of HIV infection and the development of more effective anti-HIV therapeutics.