Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US6200558A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Joseph E. Saavedra · Thurmont, US
• Larry K. Keefer · Bethesda, US
• Peter P. Roller · Rockville, US
• Miki Akamatsu · Rockville, US

Key dates

• Filing date: Apr 22, 1997
• Grant date: Mar 13, 2001
• Expiry date: Apr 22, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.