Amplifying sequences, vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells therapeutic and vaccine applications
US6201115A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 13, 1998 |
| Grant date | Mar 13, 2001 |
| Priority date | — |
| Expiry date | Nov 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Amplifying sequences, vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells, therapeutic and vaccine applications. Amplifying sequences showing a homology of at least 90% with the following SEQ ID N.degree. 1 sequence: PA1 TCTATAAATA X.sub.1 X.sub.2 X.sub.3 GC Y.sub.1 Y.sub.2 Y.sub.3 GG TATTTGGGGT TGGCAGCTGT T in which: PA2 X.sub.1, X.sub.2 and X.sub.3 may independently represent respectively C or G, C or G, and C or A PA2 Y.sub.1, Y.sub.2 and Y.sub.3 may independently represent respectively T or C, C or G, and T or C. Such sequence may included in a sequence or expression vector containing in addition a sequence coding for a protein and a promoter. Such sequences allow very strong amplification of the transcription of the gene coding for the protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.