Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists

US6211196A · kind A · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Holger Heitsch · Hofheim, DE
• Adalbert Wagner · Gersthofen, DE
• Klaus Wirth · Frankfurt am Main, DE
• Bernward Scholkens · Kelkheim, DE

Key dates

• Filing date: Mar 26, 1998
• Grant date: Apr 3, 2001
• Expiry date: Mar 26, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application describes such compounds, as well as processes for their preparation and use. The compounds according to this invention include compounds of formula (I) ##STR1## in which B, D, R.sup.1, and R.sup.2 have the meanings indicated herein.