Multideterminant peptides that elicit helper T-lymphocyte, cytotoxic T lymphocyte and neutralizing antibody responses against HIV-1

US6214347A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Jay A. Berzofsky · Bethesda, US
• Jeffrey D. Ahlers · Winterville, US
• C. David Pendleton · Bethesda, US
• Peter L. Nara · Frederick, US
• Mutsunori Shirai · Rockville, US

Key dates

• Filing date: May 31, 1995
• Grant date: Apr 10, 2001
• Expiry date: May 31, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to peptides of the HIV-1 envelope protein presenting multiple immune determinants. The peptide elicits both humoral and cell-mediated immune responses in mice having a variety of MHC types. In other embodiments, the invention is directed to immunogens composed of the peptides and methods for immunization employing them.