Inhibitors or bone reabsorption and antagonists of vitronectin receptors

US6218415A · kind A · utility

Assignees

• Hoechst GmbH · DE
• Genentech, Inc. · US

Inventors

• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Jochen Knolle · Kriftel, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Denis Carniato · Marcoussis, FR
• Jean-Francois Gourvest · Claye-Souilly, FR
• Tom Gadek · Oakland, US
• Robert McDowell · San Francisco, US

Key dates

• Filing date: Mar 20, 1997
• Grant date: Apr 17, 2001
• Expiry date: Mar 20, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors The present invention relates to 5-membered ring heterocycles of the formula I, ##STR1## in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation and to their use as medicaments. The novel compounds are used as vitronectin receptor antagonists and as inhibitors of bone reabsorption.