Nucleotide analogs

US6225460A · kind A · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• Norbert W. Bischofberger · Redwood City, US
• Robert J. Jones · Millbrae, US
• Murty N. Arimilli · Oak Ridge, US
• Kuei-Ying Lin · Fremont, US
• Michael S. Louie · Burlingame, US
• Lawrence R. McGee · Pacifica, US
• Ernest J. Prisbe · Los Altos, US
• William A. Lee · Palo Alto, US
• Kenneth C. Cundy · Redwood City, US

Key dates

• Filing date: Feb 10, 1999
• Grant date: May 1, 2001
• Expiry date: Feb 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.