Double-stranded peptide nucleic acids

US6228982A · kind A · utility

Inventors

• Benget Norden · Mölndal, SE
• Pernilla Wittung · Gothenburg, SE
• Ole Buchardt · Frederikssund, DK
• Michael Egholm · Wayland, US
• Peter Nielsen · Kokkedal, DK
• Rolf Henrik Berg · Hørsholm, DK

Key dates

• Filing date: Jul 2, 1993
• Grant date: May 8, 2001
• Expiry date: Jul 2, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3513
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.