Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephams
US6232306A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1999 |
| Grant date | May 15, 2001 |
| Priority date | — |
| Expiry date | Jun 14, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of formula I ##STR1## wherein PA1 R.sup.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkyl substituted by fluoro, or C.sub.3-6 -cycloalkyl; PA1 R.sup.2 is hydrogen or a substituent selected from the group consisting of --CH.sub.2 C(.dbd.CHR)--COOR, --CH.sub.2 OCOR, --CH(R)OCOR, --CH(R)OCOOR, --CH(OCOR)OCOR, --CH.sub.2 COCH.sub.2 OCOR and ##STR2## PA1 R.sup.3 is hydrogen or a substituent selected from the group consisting of --CH.sub.2 C(.dbd.CH.sub.2)--COOR, --COOCH.sub.2 C(.dbd.CHR)--COOR, --COOCH.sub.2 OCOR, --COOCH(R)OCOR, --COOCH(R)OCOOR, --COOCH(OCOR)OCOR, --COOCH.sub.2 COCH.sub.2 OCOR, and ##STR3## PA1 with the proviso that one of R.sup.2 and R.sup.3 is hydrogen and the other is not hydrogen, PA1 R is hydrogen or C.sub.1-6 -alkyl; PA1 R.sup.4 is hydrogen or hydroxy, PA1 R.sup.5 is hydrogen or .omega.-hydroxyalkyl; and PA1 X is CH or N, pharmaceutically acceptable salts of the compounds and hydrates of the compounds and of their salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.