Hydrazine derivatives

US6235787A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Michael J. Broadhurst · Royston, GB
• William Henry Johnson · Hitchin, GB
• Daryl Simon Walter · Harlow, GB

Key dates

• Filing date: Jun 16, 1998
• Grant date: May 22, 2001
• Expiry date: Jun 16, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Hydrazine derivatives of the formula ##STR1## wherein Y is CO or SO.sub.2 ; R.sup.1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R.sup.2 is lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl or aryl when Y is SO.sub.2 and is lower alkyl, halo-lower alkyl, lower alkoxy, lower alkoxycarbonyl, acyl, lower cycloalkyl, aryl, aryl-lower alkyl, aryl-lower alkoxy or NR.sup.5 R.sup.6 when Y is CO; and R.sup.3 is hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl or heterocyclyl; or R.sup.2 and R.sup.3 together form the residue of a 5-, 6- or 7-membered cyclic amide, cyclic imide, cyclic sulphonamide or cyclic urethane group; R.sup.4 is lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl or a group of the formula X-aryl, X-heteroaryl or --(CH.sub.2).sub.1-2 --CH.dbd.CR.sup.7 R.sup.8 ; X is a spacer group; R.sup.5 and R.sup.6 each individually are hydrogen, lower…